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Dosing and administration of IVIG:
- IVIG liquid products that have been stored in refrigerators should be allowed to come to room temperature before administration to minimize adverse effects.
- IVIG is usually administered at an infusion center or healthcare facility.
- Patients receiving IVIG should be well hydrated prior to infusion. This is particularly important for patients with risk factors for thrombosis and/or renal complications of IVIG therapy.
- Dosing varies upon whether IVIG is administered for the purpose of reducing infections or suppression of an inflammatory of autoimmune process. IVIG doses range from 400 to 800 mg/kg/month are used for immune deficiencies. Doses may be given every three to four weeks. In patients who require auto-inflammatory effects of IVIG, high doses are typically required. This will usually range from 1-2 g/kg as a single dose.
- The pharmacokinetic properties of IVIG in healthy persons are well defined and last approximately 22 days; however, in persons with certain illnesses, they can last as few as 6 days.

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