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Hello,
Dear customer

Regarding what you mentioned,

  it's very good to rule out drug interactions when you take some drugs at the same time.

What is the brufen ?

The brufen contains the active ingredient Ibuprofen when is one of the non steroidal anti inflammatory drugs.

What is the Oratane ?

This drug contains the active ingredient Isotretinoin which is one of the drugs that are prescribed for treatment of acne.

Is there an interaction  ?

There is no known interaction between those medications .

What should you do in this case ?

 we recommend that you visit your GP  doctor so  that the doctor could do a full clinical evaluation of your case in order to confirm that everything is going well.  
Stay well.
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